IndraLab

Statements

ADP inhibits NLRP3. 3 / 3
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"In septic rats, an antagonist of the adenosine diphosphate (ADP) receptor P2Y12, clopidogrel, has been shown to reduce the activity of the platelet NLRP3 inflammasome, as well as the circulating concentration of IL1β and IL18 and sepsis-induced kidney injury, supporting an immune role of platelets in sepsis through their NLRP3 inflammasome [110]."
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"CD39 expressing DCs converted extracellular ATP to ADP and AMP molecules, which were critical to down-regulate NLRP3 inflammasome and protect the host from experimental autoimmune encephalomyelitis (EAE)."
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"In septic rats, an antagonist of the adenosine diphosphate (ADP) receptor P2Y12, clopidogrel, has been shown to reduce the activity of the platelet NLRP3 inflammasome, as well as the circulating concentration of IL1β and IL18 and sepsis-induced kidney injury, supporting an immune role of platelets in sepsis through their NLRP3 inflammasome [110]."
35563812