IndraLab

Statements

OTUD5 activates TLR. 4 / 4
| 4
reach
"Some others are deubiquitinases (DUBs), such as A20 (also known as TNFAIP3), CYLD (cylindromatosis D), and DUBA (deubiquitinating enzyme A), which negatively modulate TLR signaling by removing the K63[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26276688
reach
"These results suggested that OTUD5 enhances TLR/IL-1R-mediated NF-κB and MAPK signaling."
38605168
reach
"Taken together, these findings revealed that OTUD5 stimulates TLR/IL-1R-mediated production of proinflammatory cytokines.Since TLR/IL-1R-mediated activation of NF-κB and MAPKs lead to the production of inflammatory cytokines [45, 46], we next explored the role of OTUD5 in the NF-κB and MAPK signaling pathways by transfecting Otud5-siRNA into PMs."
38605168
reach
"OTUD5 promotes TLR/IL1-R-mediated NF-kappaB and MAPK signaling."
38605168