IndraLab

Statements

COPS6 activates HYCC1. 9 / 9
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"Recent research by Li et al. demonstrated that signalosome 6 (CSN6) levels are elevated in HCC and act as an activator of hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) in the mevalonate pathway, promoting the development of tumors [127]."
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"Here it is shown that CSN6 is elevated in HCC and is a positive regulator of hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) of mevalonate (MVA) pathway to promote tumorigenesis."
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"Together, these results suggested that high CSN6 expression is important for HCC growth and correlates with poor survival.2.2 CSN6 Promotes YAP1 Activation in HCC."
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"We demonstrate that CSN6 is elevated in HCC and correlates with poor progonosis."
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"Both COPS6 and COPS9 knockdown also reduced viable HCC cell number after several days in culture as estimated by CCK8 assay, while overexpression significantly increased (Figure 11B), suggesting that COPS6 and COPS9 accelerate HCC tumor growth."
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"CSN6 promotes HCC cancer cell growth in vitro and in vivo through YAP1 nuclear translocalization and activation."
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"Both COPS6 and COPS9 overexpression promoted HCC cell migration and Matrigel invasion in transwell assays, while COPS6 siRNA transfection or COPS9 siRNA transfection repressed transwell migration and Matrigel invasion (Figure 11C)."
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"In HCC, CSN6 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis (26)."
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"With cell confluence assay and colony formation assay, we find that knockdown (KD) of CSN6 significantly inhibited tumor growth in HCC cell line in vitro (Figure S1D–F, Supporting Information)."
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