IndraLab

Statements

TNFRSF1A binds IL1B. 4 / 4
| 4
reach
"Previous studies reported that IL1beta and TNFalpha exert toxic effects by binding to their cognate receptors, IL1-R1 and TNFR1, respectively, triggering downstream signaling pathways that activate transcription factors, such as NFkappaB or AP1 which in turn lead to the production of NO and ROS."
19526281
reach
"We determined whether KCF18 can reduce the bindings of TNF-alpha and TNFR1, IL-1beta and IL-R, and IL-6 and IL-6R in liver tissues."
| PMC
reach
"In the present study, the PLA data indicated that KCF18 could simultaneously inhibit more than 70% binding of TNF-alpha to TNFR1, more than 80% binding of IL-1beta to IL-1R, and approximately 70% binding of IL-6 to IL-6R in the liver tissues of mice with endotoxemia."
| PMC
reach
"Immunofluorescence staining and the proximity ligation assay (PLA) were performed to evaluate bindings of TNF-alpha, IL-1beta, and IL-6 to TNFR1, IL-1R, and IL-6R, respectively, in liver tissues, per a previously reported method [XREF_BIBR]."
| PMC