IndraLab

Statements

USP22 increases the amount of TP53. 6 / 6
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"USP22 also play roles in cell cycle regulation, where depletion of USP22 increases the expression of p53 and p21, inhibits proliferation, and induces cell cycle arrest at G1 phase."
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"USP22 siRNA transfection increased the expression of p53 and p21, decreased cyclin E expression in bladder cancer cells."
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"In HCT116 cells, downregulation of USP22 could up-regulate the expression of p53 ( Lv et al., 2011 )."
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"In HeLa cells, knock-down of USP22 could up-regulate the expression of p53, and overexpression of USP22 could down-regulate the expression of p53."
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"In contrast, the expression of p53 was increased by Ang II infusion, and si-USP22 treatment further increased the expression of p53 (Figure 6A)."
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"The loss of USP22 can reduce the transcription of Myc and p53 by removing Ub from H2B.27 USP3 and USP21 also have functions in chromatin modification, leading to aberrant gene transcription.28 Loss of USP3 results in defects of the cell cycle, while USP21 can promote regenerative functions in hepatocytes."
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