IndraLab

Statements

MLL2 binds BAP1. 8 / 8
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sparser
"The MLL4 and BAP1 co-occupancy depends on ASXL proteins that directly interact with both MLL4 and BAP1 and bring together two enzymatic activities to specific genomic loci."
39984049
sparser
"MLL4 occupancy on MLL4 + BAP1 + genomic regions depends on functional ASXLs that interact with both MLL4 and BAP1, and CRC-relevant mutations attenuate the formation of the MLL4-ASXL complex."
39984049
sparser
"MBH of ASXL1/2 is required for the association of BAP1 with MLL4 in ESCs."
38849395
sparser
"Although ASXLs have been shown to form complexes with both the deubiquitinase BAP1 and the methyltransferase MLL4(12,15), the importance of ASXLs in genomic distribution of BAP1 and MLL4 in CRC remains unclear."
39984049
sparser
"These results indicated that BAP1 associates with MLL4 in ESCs in an ASXL1/2 MBH-dependent manner."
38849395
sparser
"To assess whether ASXLs play a role in regulating MLL4 and BAP1 binding at specific chromatin sites, we generated MLL4-, ASXL2-or BAP1-deficient human colon cancer HCT116 cells using the CRISPR/Cas9 approach."
39984049
sparser
"Interdependent genomic binding of MLL4 and BAP1 on enhancers."
39984049
sparser
"The fact that MLL4 and BAP1 do not directly interact and are linked through their concomitant binding to ASXLs suggested a possible role of ASXLs in this regulation."
39984049