IndraLab

Statements

CYLD activates IL6. 4 / 4
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"CYLD impairs production of fibrin in Listeria infection in mice by inhibiting NF-kB-mediated activation of IL-6 production and IL-6 's activation of the STAT3 pathway that leads to fibrosis [XREF_BIBR]."
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"In the present study, we found that high glucose dose- and time-dependently downregulated the protein and mRNA expressions of CYLD in GMCs (SV40 MES 13 and HBZY-1) and increased the expression levels of p-IkappaBalpha, NF-kappaBp65, and p-NF-kappaBp65, and furthermore induced the release of MCP-1, IL-6, and IL-8."
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"Nishanth G et al. [20] have demonstrated that CYLD could promote severe listeriosis through dampening IL-6/STAT3-dependent fibrin production in vivo ; Wurm R et al. [21] have show that the short form [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpressing CYLD led to significant decreases in LPS-induced TNF-α and IL-6, at both the transcription and translation levels, compared to an empty vector (EV) (Fig. 3C, D)."
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