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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

CYLD activates IL6. 2 / 2

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"In the present study, we found that high glucose dose- and time-dependently downregulated the protein and mRNA expressions of CYLD in GMCs (SV40 MES 13 and HBZY-1) and increased the expression levels of p-IkappaBalpha, NF-kappaBp65, and p-NF-kappaBp65, and furthermore induced the release of MCP-1, IL-6, and IL-8."

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"CYLD impairs production of fibrin in Listeria infection in mice by inhibiting NF-kB-mediated activation of IL-6 production and IL-6 's activation of the STAT3 pathway that leads to fibrosis [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...