IndraLab

Statements

BAP1 is phosphorylated. 4 / 4
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rlimsp
"Of note, BAP1 is a substrate of the ATM/ATR checkpoint kinases, and it is phosphorylated upon several stressors, including IR, UV light and replication stress (Matsuoka et al., 2007; Eletr et al., 2013; Ismail et al., 2014; Yu et al., 2014)."
26442100
rlimsp
"Phosphorylation of BAP1 that promotes HR resulted in reduced chromatin binding of BAP1."
30559450
rlimsp
"BAP1 phosphorylation and its own catalytic activity are required for its recruitment to double-strand DNA break lesions and promotion of DNA repair by homologous recombination [35]."
30897782
rlimsp
"The central region of BAP1 is predicted to be disordered. Sites within this central region have been identified as important for binding non-ASXL complex components; for example, the HCF-binding motif and the phosphorylated threonine residue that mediates BAP1's interaction with FOXK2 have been mapped to this region [96,97]. Additionally, phosphorylation of six sites within this region has been shown to be important for BAP1's role in DNA double-strand break repair [88]."
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