IndraLab

Statements

USP47 activates SATB1. 8 / 8
| 8
reach
"The deficiency of USP47 impaired the transcriptional activity of SATB1 target genes and inhibited cell proliferation, migration, and tumorigenesis in a mouse model of colon cancer."
34604226
reach
"These results suggested that USP47 could mediate EMT by stabilizing SATB1 (Yu et al., 2019)."
34604226
reach
"USP47 deficiency impairs transcriptional activity of SATB1 target genes and inhibits proliferation, migration, and tumorigenesis (68, 69)."
40071088
reach
"As shown in Fig. 2 G and H, and S3B , the catalytically inactive USP47/CS mutant failed to protect SATB1 from degradation, implying that deubiquitinase activity is required for USP47-mediated SATB1 st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30742943
reach
"Likewise, knockdown of USP47 in HCT116 cells promoted SATB1 degradation ( Fig. S3C )."
30742943
reach
"In addition, we determined whether USP47-mediated SATB1 stability is achieved via proteasomes."
30742943
reach
"As seen from Fig. 2 I, MG132 (proteasome inhibitor) treatment could rescue the USP47 knockout-mediated degradation of the SATB1 protein."
30742943
reach
"We also provided evidence that USP47 positively regulated SATB1 stability."
30742943