IndraLab

Statements

Ile-His inhibits KCNH2. 2 / 2
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"These results demonstrate that activation of calpains by ROS dependent elevation of [Ca (2+)] i mediates hERG protein degradation by IH."
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"IH increased reactive oxygen species (ROS) levels, intracellular Ca (2+) concentration ([Ca (2+)] i), calpain enzyme activity, and hERG protein degradation, and all these effects were prevented by manganese-(111)-tetrakis-(1-methyl-4-pyridyl)-porphyrin pentachloride, a membrane-permeable ROS scavenger."
26659724