IndraLab

Statements

USP22 decreases the amount of FOXP3. 2 / 2
| 2
reach
"Screen hits were confirmed using individual ribonucleoprotein sgRNA-Cas9 complexes (RNPs), which showed that targeting Usp22 in both mouse and human Tregs (USP22) decreased FOXP3 expression, again suggesting a role in positively regulating FOXP3 expression."
33812776
reach
"T reg -specific ablation of Usp22 in mice reduced Foxp3 protein levels and caused defects in their suppressive function that led to spontaneous autoimmunity but protected against tumour growth in multiple cancer models."
32499641