IndraLab

Statements

USP22 decreases the amount of FOXP3. 4 / 4
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"T reg -specific ablation of Usp22 in mice reduced Foxp3 protein levels and caused defects in their suppressive function that led to spontaneous autoimmunity but protected against tumour growth in multiple cancer models."
32499641
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"Screen hits were confirmed using individual ribonucleoprotein sgRNA-Cas9 complexes (RNPs), which showed that targeting Usp22 in both mouse and human Tregs (USP22) decreased FOXP3 expression, again suggesting a role in positively regulating FOXP3 expression."
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"Therefore, these results indicate that Usp22i-S02 is a potent Usp22-specific small-molecule inhibitor that down-regulates Foxp3 expression in T cells in a Usp22- but not Usp21-dependent manner."
36427305
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"Deletion of Usp22 drives reduction in Foxp3 transcript levels and through increased ubiquitin at the chromatin level ultimately leading to Foxp3 degradation."
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