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Pyraclofos activates KCNH1. 4 / 4
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"Thus, our positive controls confirm the ability of recording hErg1 using the voltage protocol and ion composition of the solutions optimized for hErg1 (Figure 2A) and gives information about the shape of the hEag1 current driven by the hErg1 voltage protocol (Figure 2B)."
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"To test the voltage-dependent activation of hEAG1 channels, 1-s pulses from −100 mV to +120 mV in 10-mV steps were used to activate the channel from a holding potential of −120 mV, followed by a 400-m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"At this voltage, assuming that hEAG1 and Kv1.2/2.1 XREF_BIBR activate in a similar fashion, the voltage sensors are expected to be fully activated, placing hEAG1 K327 through R336 on the extracellular side and R339 interacting with negatively charged residues in S2 and S3."
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"Furthermore, evidence has been presented that the detailed molecular rearrangements that contribute to voltage-dependent activation in eag and Shaker channels are conserved, justifying the combination[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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