IndraLab

Statements

KCN inhibits KCNH2. 22 / 22
| 1 21
sparser
"The toxicity profile of sesamin has been predicted based on eye corrosion, hepatotoxicity, AMES toxicity, and hERG potassium channel inhibition."
35223101
sparser
"In the ADMET profile, RK-59638 showed a good plasma protein binding ratio (85%), membrane permeability (29.2 × 10 –6 cm/s), in vitro toxicity (78% viability at 30 μM for HepG2 cells), and hERG potassium channel inhibition (25.4% inhibition at 10 μM)."
32478230
sparser
"Here we show that clinical concentrations of psilocin do not cause significant human ether-a-go-go-related gene (hERG) potassium channel inhibition, a major risk factor for adverse cardiac events."
34871422
sparser
"The toxicity profile of all the identified phytoconstituents from S. repanda ethanolic crude extract has been predicted based on AMES toxicity, hepatotoxicity, hERG potassium channel inhibition and skin sensitization parameters."
33540783
sparser
"Lastly, early safety assessments done across different enzymatic assays indicated that GSK-693 did not show any sign of cytotoxicity and no hERG potassium channel inhibition [ xref ], suggesting a low risk for general toxicity and cardiotoxicity observed in isoniazid."
34068171
sparser
"Moreover, the hepatotoxicity, skin sensitization, the hERG potassium channel inhibition, AMES toxicity, human maximum tolerated dose, carcinogenicity, oral rate acute, and chronic toxicity were predicted via pkCSM web server [13] at the default settings via submitting of the chemical structures in smile format."
32226726
reach
"Although TdP usually ends spontaneously, it can rarely turn into ventricular fibrillation and cardiac arrest with a potentially lethal outcome.The mechanism of QTc time prolongation by LPV/r, HCQ and erythromycin is through inhibition of the cardiac hERG (human ether-a-go-go related gene) potassium channels 13 ."
34285902
sparser
"While testing for hERG potassium channel inhibition and QT prolongation has prevented torsade de pointes (TdP) inducing drugs from reaching the market, other new drugs are dropped from development, sometimes inappropriately ( xref )."
27701120
sparser
"The results outlined that sesamin showed toxicity only in the AMES test rather than eye corrosion, hepatotoxicity, hERG potassium channel inhibition, and T. pyriformis ."
35223101
sparser
"Screening of drug candidates for hERG potassium channel inhibition has become an early step in testing for potential drug dependent long QT syndrome that is linked to sudden death [ xref ]."
29340047
sparser
"Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide."
34785211
sparser
"Among them, compound 5 displayed strong triple-target bioactivities in vitro, low hERG potassium channel inhibition and acceptable brain distribution."
34922191
sparser
"GSK693 did not show any sign of cytotoxicty and no hERG potassium channel inhibition ( xref ), suggesting a low risk for general toxicity and cardiotoxicity."
27428438
sparser
"The most interesting result of this study was the very positive effect of the 3,5-dialkoxy-4-pyridyl C-unit substitution on hERG potassium channel inhibition."
30803745
sparser
"The authors demonstrated a high vulnerability to tachycardia of tachypaced hiPS-CMs, terminated by ryanodine receptor stabilization or sodium or hERG potassium channel inhibition, hence indicating this new model as a potential tool to test anti-arrhythmic drugs to treat ventricular tachycardia [ xref ]."
32403456
sparser
"We have subjected the compounds to preliminary cytotoxicity studies on human HUVEC and HepG2 cell lines and determined their hERG (human ether-a-go-go-related gene) potassium channel inhibition (Supplementary Table  xref )."
33420011
sparser
"However, medium risk for human ether-a-go-go-related gene (hERG) potassium channel inhibition was predicted."
| PMC
sparser
"The AMES toxicity, hepatotoxicity, hERG potassium channel inhibition and skin sensitization parameters were predicted to find out the toxicity profile of the identified phytochemical constituents from the E. sativa crude extract."
35209197
sparser
"We demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition."
31598634
sparser
"Results of compound 1G showed no hERG (human ether-a-go-go-related gene) potassium channel inhibition in human, similar to standard drug topotecan, which otherwise may cause risk of cardiotoxicity."
29615704
sparser
"Thus, a fluorescence polarization assay was carried out to determine the potential hERG potassium channel inhibition of 22 in comparison with lead compound 1 and the references HF and LUM ( xref )."
33666415
sparser
"Further biological evaluation revealed that it did not show obvious cytotoxicity and hERG potassium channel inhibition at micromolar concentration."
26479744