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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP8 inhibits cilium assembly. 2 / 2

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"CRL3KCTD17 , USP8 , and TCHP TCHP , a centriolar protein originally identified as a keratin-binding protein , activates AURKA and suppresses ciliogenesis [ 101,141,142 ] ."

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"USP8 phosphorylation on Tyr717 and Tyr810 by EGFR kinase elevates its activity and then activates an inhibitory mechanism of ciliogenesis, i.e., EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase [24]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...