IndraLab

Statements

USP8 inhibits cilium assembly. 4 / 4
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"Knockdown of KCTD17 shortened primary cilia of hTERT-RPE1 cells through inhibition of proteolysis of TCHP, whereas knockdown of USP8 increased the ciliogenesis through stimulation of proteolysis of TCHP (Kasahara et al., 2014; Kasahara et al., 2018)."
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"USP8 phosphorylation on Tyr717 and Tyr810 by EGFR kinase elevates its activity and then activates an inhibitory mechanism of ciliogenesis, i.e., EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase [24]."
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"Knockdown of EGFR or USP8 suppressed the TCHP-AurA pathway, induced unscheduled ciliogenesis, and caused cell cycle arrest of RPE1 cells, even in the presence of serum."
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"CRL3KCTD17 , USP8 , and TCHP TCHP , a centriolar protein originally identified as a keratin-binding protein , activates AURKA and suppresses ciliogenesis [ 101,141,142 ] ."
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