IndraLab

Statements

OTUD4 binds SERPINE1. 7 / 7
2 | 5
sparser
"Through protein profile screening, we found that OTUD4 may interact with protein PAI-1."
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sparser
"Further immunofluorescent stanning and co-immunoprecipitation proved that OTUD4 was associated with PAI-1 (Fig. xref )."
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sparser
"We further confirmed that OTUD4 interacted with PAI-1 for de-ubiquitination and inhibiting CSE induced PAI-1 degradation."
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sparser
"Our data indicated that OTUD4 is associated with PAI-1, a serine protease inhibitor (SERPIN), which is related to ubiquitin proteasome degradation in the regulating of cell death and was reported to promote angiogenesis and tumor cell survival by preventing apoptosis [ xref – xref ]."
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biogrid
No evidence text available
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biogrid
No evidence text available
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sparser
"Here, we found that OTUD4 interacts with PAI-1 and removes its K48-linked ubiquitination."
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