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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TP53 binds MDM2 and NCL. 5 / 5
| 5
sparser
"Previous studies had revealed that nucleolin binds Mdm2 to regulate p53 ubiquitination, and HAUSP can form a complex with Mdm2 and p53 xref xref ."
sparser
"NCL interacts with both HDM2 and P53 [ xref , xref ] to regulate P53 stability."
sparser
"Moreover, upon DNA damage, NCL forms a ternary complex with P53 and HDM2, which recruits the ubiquitin protease HAUSP."
sparser
"Analogous to NPM1, NCL interacts with MDM2, disrupting its association with p53 [ xref ]."
sparser
"Nucleolin directly interacts with Hdm2 and p53 by distinct domains in vitro."