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EMMAA Bob with Bioagents

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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

TP53 binds MDM2 and NCL. 5 / 5

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"NCL interacts with both HDM2 and P53 [ xref , xref ] to regulate P53 stability."

28671574

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"Analogous to NPM1, NCL interacts with MDM2, disrupting its association with p53 [ xref ]."

29429989

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"Previous studies had revealed that nucleolin binds Mdm2 to regulate p53 ubiquitination, and HAUSP can form a complex with Mdm2 and p53 xref xref ."

26238070

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"Moreover, upon DNA damage, NCL forms a ternary complex with P53 and HDM2, which recruits the ubiquitin protease HAUSP."

28671574

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"Nucleolin directly interacts with Hdm2 and p53 by distinct domains in vitro."

22103682

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