"Previous studies had revealed that nucleolin binds Mdm2 to regulate p53 ubiquitination, and HAUSP can form a complex with Mdm2 and p53 xref xref ."
"NCL interacts with both HDM2 and P53 [ xref , xref ] to regulate P53 stability."
"Moreover, upon DNA damage, NCL forms a ternary complex with P53 and HDM2, which recruits the ubiquitin protease HAUSP."
"Analogous to NPM1, NCL interacts with MDM2, disrupting its association with p53 [ xref ]."
"Nucleolin directly interacts with Hdm2 and p53 by distinct domains in vitro."