IndraLab

Statements

Dexmedetomidine inhibits NLRP3. 8 / 8
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"In acute kidney injury induced by lipopolysaccharide, dexmedetomidine inhibited NLRP3 activation by regulating the TLR4/NOX4/NF-κB pathway, thereby reducing disease development."
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"Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4 and NFkappaB."
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"Recently , the roll of the inhibition of Nod-like receptor pyrin domain 3 ( NLRP3 ) inflammasome by dexmedetomidine was investigated ."
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"Cheng et al. demonstrated that dexmedetomidine could inhibit the NF-κB pathway and NLRP3 inflammasome to reduce the maturation and release of inflammatory factors in the cartilage tissue to attenuate papain-induced OA in rats [24]."
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"Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats."
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"Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats."
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"Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats."
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"A recent study showed that dexmedetomidine, a sedative small molecule drug, inactivated NLRP3 through the suppression of NF-κB and JNK signals, subsequently alleviating pyroptosis during inflammation and IDD 74."
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