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Dexmedetomidine inhibits NLRP3. 17 / 17
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"In addition, silymarin, atorvastatin, baicalein, mst4, h2s, a68930-induced activation of drd1, fimasartan, p2y6 receptor activation, histone deacetylation 10, verbascoside, verapamil, cordycepin, dexmedetomidine, andrographolide and others can directly or indirectly inhibit NLRP3 activation to reduce nerve inflammation, improve secondary brain injury after ICH, and play a neuroprotective role [83–96]."
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"A recent study showed that dexmedetomidine, a sedative small molecule drug, inactivated NLRP3 through the suppression of NF-κB and JNK signals, subsequently alleviating pyroptosis during inflammation and IDD 74."
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"Thus, the anti-inflammatory effects of dexmedetomidine inhibit NLRP3-derived inflammasome, modulating the c-fos upregulated expression [155]."
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"In acute kidney injury induced by lipopolysaccharide, dexmedetomidine inhibited NLRP3 activation by regulating the TLR4/NOX4/NF-κB pathway, thereby reducing disease development."
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"Application of dexmedetomidine to AKI rats can reduce the activation of NLRP3 inflammasome and the expression level of IL‐18, enhance autophagy, and protect the kidney [13]."
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"Similarly, dexmedetomidine (an inhibitor of apoptosis and NLRP3) has shown a significant reduction in the apoptotic cell death with improvements in behavioural outcomes on post-injury administration alone and in combination with BAY 11-7082 (NF-kB inhibitor) [265]."
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"A recent study suggested that the NLRP3 inflammasome inhibited by dexmedetomidine led to an attenuation of papain-induced OA in rats [ 19 ]."
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"Rapamycin, dexmedetomidine and JC124 (small molecule inhibitors for NLRP3) significantly reduces the levels of inflammatory markers IL-1β, TNFα, iNOS and caspase-1 in a post-injury treatment paradigm [263-266].4.2 Oxidative Stress Pathway Targeting in TBI."
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"Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats."
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"In lipopolysaccharide-induced acute kidney injury, dexmedetomidine inhibited NLRP3 activation by regulating the TLR4/NOX4/NF-κB pathway, thereby reducing disease development [45]."
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"Cheng et al. demonstrated that dexmedetomidine could inhibit the NF-κB pathway and NLRP3 inflammasome to reduce the maturation and release of inflammatory factors in the cartilage tissue to attenuate papain-induced OA in rats [24]."
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"Recently , the roll of the inhibition of Nod-like receptor pyrin domain 3 ( NLRP3 ) inflammasome by dexmedetomidine was investigated ."
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"In a rat model of SAH, dexmedetomidine was also found to reduce the neutrophil infiltration, microglial activation, pro-inflammatory factor release, and cell apoptosis (at 24 hours after SAH) by suppressing the TLR4/NF-κB pathway and the NLRP3 inflammasome (Yin et al., 2018)."
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"Evidence from Wu et al. demonstrated that dexmedetomidine inhibited NLRP3 inflammatory corpuscles and alleviated liver I/R damage by activating PI3K/AKT/Nrf2 pathway [16]."
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"Compared with the TAA and DY groups, the expression of aforementioned indicators was significantly reduced in the D1 and D2 groups ( P < 0.01), indicating that dexmedetomidine could significantly inhi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4 and NFkappaB."
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"Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats."
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