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USP2 activates cell death. 2 / 3

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"Accordingly, overexpression of a catalytically active UBP41 allele was shown to induce cell death in several cancer cell lines [41] ."

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"Moreover, USP2 silencing enhanced the iron ion concentration and lipid peroxidation accumulation as well as suppressed ferroptosis, while upregulating USP2 promoted ferroptotic cell death in ESCC cells."

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USP2 activates cell death. 2 / 3

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