IndraLab

Statements

USP10 inhibits PTEN. 9 / 9
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"USP10 was reported to inhibit tumor growth and inactivate mTORC1 and AKT signaling by stabilizing AMPKalpha and PTEN in HCC cells."
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"The IB assays showed that introduction of USP10 markedly increased but TRIM25 reduced the localization of PTEN to plasma membrane (Fig. 5I), which is consistent with the previous finding (10)."
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"To our attention, USP10 was also found to suppress the AKT/mTOR signaling pathway by inhibiting PTEN, but the underlying mechanisms are controversial."
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"He et al., also illustrated that USP10 inhibits non-small cell lung cancer cell proliferation by restoring PTEN activity (He et al. 2021)."
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"USP10 has been reported to promote cell proliferation of hepatocellular carcinoma via deubiquitinating and stabilizing YAP/TAZ [29]; USP10 suppresses the growth and invasive capacity of lung cancer cells by overexpressing PTEN [30]; USP10 modulates oncogene-induced senescence through deubiquitination and stabilization of p14ARF [31]; USP10 propels cell proliferation in colon cancer through deubiquitinating and stabilizing Musashi-2 [32]."
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"Furthermore, USP10 inhibited lung cancer cell growth and invasion by upregulating PTEN ."
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"Moreover , USP10 , but not its inactive C424A deubiquitinating mutant or other deubiquitinases , abolished PTEN from K63-linked polyubiquitination mediated by TRIM25 ."
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"USP10 suppresses lung cancer cell invasion and growth via upregulating PTEN [22]."
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"Mechanistically, overexpressing USP10 inhibited PI3K/AKT pathway by activating PTEN."
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