IndraLab

Statements

TARDBP binds USP19. 2 / 2
| 1 1
sparser
"TDP-43 is associated with USP19 and the ER compartments and is engulfed in different intracellular compartments."
39948244
reach
"Additionally, co-immunoprecipitation experiments demonstrated interactions between USP19 and TDP-43 thus suggesting that part of TDP-43 could be secreted in a form of a tri-complex ER-USP19-TDP-43 engulfed into secretory compartments.To gain a clearer understanding of the cellular mechanisms involved in the misfolded TDP-43 secretion via the MAPS pathway, we evaluated the impact of the Spautin1 and LY294002 inhibitors on the early steps of phagophores/autophagosomes biogenesis [45, 46]."
39948244