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"Our data also indicate that the catalytic domain of USP18 interacts with DBD of STAT1 (Fig.  xref A,D) suggesting that STAT1 and STAT2 both may have a role in recruiting USP18 to IFNAR2."

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"ISGF3 binds the IFN-sensitive response element (ISRE) within ISG promoters, increasing transcription and expression of hundreds of ISGs, including ISG15 and its conjugating enzymes Ube1L, UbcH8, EFP, TRIM25, and HERC5, as well as USP18 (FIG."