IndraLab

Statements

FGFR1 activates TNFAIP3. 3 / 3
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"TNFAIP3, a ubiquitin-editing enzyme, is upregulated by iFGFR1 signaling in a FGFR1 kinase activity and in an ERK2-dependent manner."
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"Furthermore, KO of ERK2 completely abolished the FGFR1 signaling-induced TNFAIP3 upregulation, while KO of ERK1 showed little effect on TNFAIP3 expression."
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"For example, activation of FGFR1 signaling can upregulate TNFAIP3 to promote the proliferation and tumorigenesis of premalignant human mammary epithelial cells 15."
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