IndraLab

Statements

OTULIN inhibits necroptotic process. 5 / 5
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"Indeed, our data also revealed that OTULIN deficiency increases the sensitivity of osteosarcoma cells to apoptosis and necroptosis induced by cisplatin."
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"Our data suggest that OTULIN loss promotes necroptosis and enhances RIPK1 Met1- and Lys63-Ub.To determine whether the catalytic activity of OTULIN mediated its function in cell death, we stably recons[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice."
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"This phosphorylation is counterbalanced by the action of dual-specificity phosphatase 14 (DUSP14), identified as an OTULIN phosphatase that limits necroptosis."
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"OTULIN positively affects LUBAC by inhibiting its auto-ubiquitination, and OTULIN deficiency leads to TNFα-induced apoptosis and necroptosis (94, 95)."
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