IndraLab

Statements

Salicylic acid inhibits NFKB1. 11 / 11
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"The recent report demonstrated that salicylate like drugs, but not indomethacin, inhibit the activation of NF-KB by Lipopolysaccharides (LPS) (24)."
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"Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase, a key enzyme in NF-kappaB activation."
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"Sodium salicylate and prostaglandin A1 that inhibit NFk-B activity and restore growth control are experimental therapies for cylindromas."
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"Recent experiments from our group [25] demonstrated that salicylic acid treatment (an inhibitor of some prostaglandin and cyclooxygenase pathways and NFKB) can inhibit UV- and cisplatin mediated HIV i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is pertinent that the NSAIDs aspirin and salicylate have long been known to also inhibit NFkB signaling by blocking IKKbeta activity [XREF_BIBR], most probably via the same thiol-reactive quinone type of irreversible binding interaction."
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"The treatmentwith a non-steroidanti-inflammatory drug, such as a fluorated salicylate, which blocks con- stitutive NF-KB activation in the postnatal brain in vivo (Acarin et al., 2OOOc), has shown tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been demonstrated, in human and mouse cell lines, that aspirin and sodium salicylate inhibit the activation of NFKB without af- fecting other transcription factors (Kopp and Ghosh, 1994)."
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"Salicylate probably inhibits NF-KB activation through an antioxidant mechanism : nonsalicylate cyclooxygenase inhibitors do not block NF-KB activation."
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"Recent X-ray crystal analysis of DNA complex of p50 homodimer showed that the Rel homology region of p50 consists of two domains with immunoglobulin like structure and loops between anti- parallel 13-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The amount of IKB-a in activated cells was reduced relative to untreated controls suggestingthat sodium salicylate may inhibit the activation of NFKB by interfering with the pathway resulting in the p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ASA and sodium salicylate have been reported to inhibit activation of the transcription factors NFKB XREF_BIBR."
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