IndraLab

Statements

Shikonin inhibits CASP1. 6 / 6
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"First, shikonin is known to directly inhibit caspase 1 activity ( Zorman et al., 2016 ) although our results suggested that there are other pathways for regulating KAP1 stability."
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"Further, we observed that shikonin concentration-dependently inhibited the secretion and processing of pro-caspase-1 from primed and nigericin treated macrophages (XREF_FIG)."
27467658
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"In the in vitro assay using isolated caspase-1, we showed that shikonin directly inhibits caspase-1 in the same concentration range as the conventional caspase inhibitor Z-VAD-FMK (XREF_FIG)."
27467658
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"Collectively, our data demonstrated that shikonin concentration-dependently inhibits inflammasome activation by acting directly on caspase-1, however further studies are needed to elucidate the exact mechanism of shikonin inhibition of caspase-1 activity."
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"Meanwhile, shikonin directly inhibits caspase-1 enzymatic activity and the oligomerization of apoptosis-associated speck-like proteins containing caspase recruitment domains (ASC), which is necessary for NLRP3 inflammasome activation [16]."
38671980
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"In LPS primed BMDMs, PMA differentiated THP1, and PMs, shikonin significantly inhibited caspase-1 activation triggered by stimulation with ATP or poly (dA : dT), but not MDP or flagellin (XREF_FIG and XREF_SUPPLEMENTARY)."
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