IndraLab

Statements

Mutated KCNH2 inhibits KCN. 2 / 2
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"Importantly, reduction of the cardiac rapid delayed rectifier potassium channel caused by loss-of-function mutations of the hERG channel will prolong the ventricular action potential, elongate the QTc interval, and cause a lethal arrhythmia."
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"It has been reported that hERG mutations inactivate cell membrane potassium channels and affect the imbalance of Ca and Na both inside and outside the cells, leading to cell apoptosis and affecting cardiac structural abnormalities [7]."
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