IndraLab

Statements

KCNH2 inhibits effect. 2 / 2
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"In agreement with data obtained from HEK 293 cells, partial (S631A, data not shown) or complete (S620T, xref ) attenuation of inactivation by channel mutagenesis did not abolish the activating potency of KB130015 but slightly reduced its hERG1 inhibiting effect."
20097192
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"In contrast, it also has been reported that a H 2 O 2 -dependent increase of hERG1 current activity promoted caspase-3 activation in several cancer cell lines including SKBr3. xref This effect was inhibited by the hERG1 blocker dofetilide. xref "
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