IndraLab

Statements


USP14 inhibits Wnt. 5 / 5
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"Downregulation of USP14 Suppresses the Activation of Wnt and beta-Catenin Signaling Pathway in ESCC Cells."

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"Increased Wnt reporter activity upon ectopic expression of Dvl, but not beta-catenin, was reduced by expression of Usp14-CA (XREF_FIG)."

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"Accordingly, transient overexpression of Usp14-CA reduced Wnt reporter activity (XREF_SUPPLEMENTARY)."

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"Depletion of Usp14 attenuated downstream Wnt signalling which was further evidenced when correlation between the levels of Usp14 and beta-catenin in colon tissues was observed."

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"These data suggest that knockdown of USP14 inhibits the proliferation and tumorigenesis in ESCC cells by suppressing and inhibiting the Wnt and beta-catenin signaling pathway."