IndraLab

Statements

Hexadecanoic acid inhibits NLRP3. 18 / 18
| 18
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"In vitro, nebivolol treatment of palmitate incubated H9C2 cells suppressed autophagy, restored mitochondrial biogenesis, leading to decreased mitochondrial reactive oxygen species (mtROS) generation, and suppressed NLRP3 inflammasome activation."
27686325
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"Intriguingly, treatment with the saturated fatty acid palmitate, which has been suggested to limit NLRP3 localization to mitochondria by diminishing the content of cardiolipin [25], also reduces the interaction between ER and mitochondria [73, 74]."
38862500
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"miR-132 serves as a negative feedback regulator in PA induced NLRP3 inflammasome activation via FOXO3 down-regulation."
29258239
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"Collectively, these data suggest that miR-132 is an important modulator that plays a negative role in PA induced NLRP3 inflammasome activation, at least in part through FOXO3."
29258239
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"Mechanistically, PA treatment suppressed the nuclear factor-κB (NF-κB) p65 nuclear translocation and nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome activation."
35567986
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"RIPK2 ablation, palmitate treatment, and mevalonate kinase-deficiency also reduce autophagy and mitophagy, increase mtROS, and enhance NLRP3 activation."
25879282
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"Western blotting analysis of NLRP3 protein in cell lysates and supernatants revealed that the miR-132 mimic decreased the expression and release of the PA induced NLRP3 inflammasome component (XREF_FIG B)."
29258239
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"This second hypothesis could fit with our results showing a significant inhibitory effect mediated by oleate in PA induced NLRP3 inflammasome activation [100]."
25175736
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"Gryllus bimaculatus extract has an inhibitory effect on LPS or palmitate induced NLRP3 inflammasome activation."
| PMC
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"In conclusion, our study demonstrated that PA induces ERS in HepG2 cells and subsequently activates downstream NLRP3 inflammasome-mediated cellular injury, while PCB2 inhibits NLRP3/caspase 1/IL-1beta pathway, inflammation, and apoptosis with the presence of ERS, thereby promoting cell survival, which may provide pharmacological evidence for clinical approaches on NAFLD."
34956386
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"However, SalA treatment had no inhibitory effects on the PA induced activation of the NLRP3 inflammasome and the pro inflammatory cytokine secretion in TXNIP siRNA transfected HepG2 cells."
27345365
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"Different FFAs play distinct roles; for example, palmitate promotes IL-1β and IL-18 secretion in a dose-dependent manner , whereas omega-3 fatty acids can inhibit the NLRP3 inflammasome via GPR120 and GPR40 ."
31337751
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"In summary, our study identifies miR-132 as an important and novel negative feedback regulator of PA induced NLRP3 inflammasome activation in THP-1 cells."
29258239
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"In addition, CsA abolished the ability of Hst to decrease IL-1β production, NLRP3, and cleaved caspase-1 in PA-treated HepG2 cells (Figure 6A–C)."
38809522
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"In summary, the PKR inhibitor C16 acts on the PKR and eIF2alpha signal pathway to inhibit NF-kappaB activation and suppresses the NLRP3 pyroptosis signal pathway, which are both associated with mediation of inflammatory responses."
33017381
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"In contrast, overexpression of XIAP in hepatic cell lines resulted in the decrease of PA-induced NLRP3 activation, suggesting that XIAP mitigates lipid metabolism imbalance through the regulation of NLRP3-associated inflammatory responses in vitro."
31841118
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"Furthermore, oleic acid, reduces the secretion of IL-1b by bone marrow-derived macrophages upon previous stimulation with either LPS or palmitate, supporting that mono-unsaturated FAs can also prevent the over-activation of the NLRP3 inflammasome via the activation of the AMPK pathway [60] (Table 1)."
39083430
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"These results suggest that ASP could inhibit the activation of NLRP3 inflammasome, reduce the production of PA-induced inflammatory cytokines in HepG2 cells, and inhibit NLRP3 inflammasome."
36641101