IndraLab

Statements

Hexadecanoic acid inhibits NLRP3. 8 / 8
| 8
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"In contrast, overexpression of XIAP in hepatic cell lines resulted in the decrease of PA-induced NLRP3 activation, suggesting that XIAP mitigates lipid metabolism imbalance through the regulation of NLRP3-associated inflammatory responses in vitro."
31841118
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"In vitro, nebivolol treatment of palmitate incubated H9C2 cells suppressed autophagy, restored mitochondrial biogenesis, leading to decreased mitochondrial reactive oxygen species (mtROS) generation, and suppressed NLRP3 inflammasome activation."
27686325
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"In summary, the PKR inhibitor C16 acts on the PKR and eIF2alpha signal pathway to inhibit NF-kappaB activation and suppresses the NLRP3 pyroptosis signal pathway, which are both associated with mediation of inflammatory responses."
33017381
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"Mechanistically, PA treatment suppressed the nuclear factor-κB (NF-κB) p65 nuclear translocation and nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome activation."
35567986
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"RIPK2 ablation, palmitate treatment, and mevalonate kinase-deficiency also reduce autophagy and mitophagy, increase mtROS, and enhance NLRP3 activation."
25879282
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"Gryllus bimaculatus extract has an inhibitory effect on LPS or palmitate induced NLRP3 inflammasome activation."
| PMC
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"Different FFAs play distinct roles; for example, palmitate promotes IL-1β and IL-18 secretion in a dose-dependent manner , whereas omega-3 fatty acids can inhibit the NLRP3 inflammasome via GPR120 and GPR40 ."
31337751
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"In conclusion, our study demonstrated that PA induces ERS in HepG2 cells and subsequently activates downstream NLRP3 inflammasome-mediated cellular injury, while PCB2 inhibits NLRP3/caspase 1/IL-1beta pathway, inflammation, and apoptosis with the presence of ERS, thereby promoting cell survival, which may provide pharmacological evidence for clinical approaches on NAFLD."
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