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"Thus, to examine the mechanisms underlying Ang-II redox signaling, we turned to the Ang II-induced CaMKII activation shown previously to downregulate the Kv4.3 K + channel, which is produced by mRNA destabilization induced by AUF1 protein binding to the Kv4.3 3′ untranslated region (3′ UTR) in response to CaMKII phosphorylation xref xref xref ."