IndraLab

Statements

Barium(2+) inhibits NFKBIA. 6 / 6
| 5 1
reach
"BA suppressed the activation of IkappaBalpha kinase, thus abrogating the phosphorylation and degradation of IkappaBalpha."
12960358
reach
"BA further increased phospho-IkappaBalpha and phospho-p65 and decreased total IkappaBalpha compared to 2ME2 or Doc alone in LN-AI and DU145 cells, suggesting enhancement of NF-kappaB activity."
20618955
reach
"Both BA forms induced IkappaBalpha degradation, indicative of NF-kappaB activation, to comparable extents (XREF_FIG)."
28400473
reach
"Mechanistically, BA suppressed the NF-kappaB/IkappaBalpha axis in LPS-stimulated HMEECs."
39822380
sparser
"Also, one of the recommended mechanisms of these changes was the antioxidant activity of BA. xref , xref Ahangarpour et al ., xref confirmed the results of Lingaraju et al . xref A study showed that BA could inhibit IκBα (NF-κB inhibitor protein) destruction and NF-κB activity in kidneys of diabetic rats and caused a decrease in fibronectin expression, thereby preventing kidney fibrosis in diabetic patients. xref "
34345387
reach
"IKBa demonstrated strong inward rectification and was inhibited by Ba (2+) in a dose- and voltage dependent fashion, with the K (d) decreasing with hyperpolarization."
17091215