IndraLab

Statements

ZDHHC2 palmitoylates USP19. 3 / 3
| 3
sparser
"ZDHHC2 is transcriptionally upregulated by a FOXA1/CXXC5/TET2 complex and promotes S‐palmitoylation of the deubiquitinase USP19, which impairs its interaction with ACSL4."
41126755
sparser
"This hypothesis was supported by co‐immunoprecipitation assays, which demonstrated that wild‐type ZDHHC2 overexpression significantly reduced the ACSL4‐USP19 protein–protein interaction (Figure  xref ; Figure  xref , Supporting Information ), but did not influence the binding between ACSL4 and the USP19 C152S mutant, which cannot be palmitoylated by ZDHHC2 (Figure  xref )."
41126755
sparser
"In brief, our results demonstrated that ZDHHC2 palmitoylates the deubiquitinase USP19, weakening the binding between USP19 and ACSL4, thereby promoting the ubiquitin‒proteasome degradation of ACSL4 (Figure  xref )."
41126755