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COPS6 increases the amount of SIRT2. 2 / 2
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"However, the molecular mechanism of SIRT2 were down-regulated in Ang II-induced hypertrophic cardiomyocytes is still unclear.In this study, we found that CSN6 was up-regulated in hypertrophic hearts a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A recent study reported that CSN6 is elevated in angiotensin II-induced hypertrophic mouse hearts and that the overexpression of CSN6 in neonatal rat cardiomyocytes induces hypertrophy, possibly by controlling the neddylation of CRLs and consequent regulation of SIRT2 protein levels [54]."
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