IndraLab

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CDK11 p46 phosphorylates EIF3F. 15 / 15
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"We identified another phosphorylation site (Thr119) in eIF3f that is phosphorylated by CDK11 p46 during apoptosis."
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"We have also presented data to show the direct phosphorylation of eIF3f by CDK11 p46 endogenously which confirmed our previous observations."
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"Based on our observations, the model that we propose depicts that the phosphorylation of eIF3f by CDK11 p46 enhances its binding to different sub-fractions of the eIF3 complex during apoptosis."
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"CDK11 p46 phosphorylates eIF3f at more than one site during apoptosis."
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"Phosphorylation of eIF3f by CDK11 p46 regulates its function in translation and apoptosis."
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"This result strongly suggests that eIF3f is directly phosphorylated by CDK11 p46 in living cells."
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"The biological consequence of the phosphorylation of eIF3f by CDK11 p46 during apoptosis is not known."
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"Endogenous phosphorylation of eIF3f by CDK11 p46."
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"This data is consistent with our previous in vitro kinase assay data and endogenous serine phosphorylation data that eIF3f is phosphorylated by CDK11 p46 after apoptotic stimulation, especially around 36 h [XREF_BIBR]."
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"To investigate whether the specific eIF3f phosphorylation by CDK11 p46 alters the association between eIF3f and eIF3 core complex, we performed co-immunoprecipitation with specific antibodies against the eIF3b and eIF3f in eIF3f, eIF3f SATA or eIF3f SETE (phosphorylation mimic mutant) transfected cells."
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"To examine whether phosphorylation of eIF3f by CDK11 p46 regulates its function, we mutated the Ser46 and Thr119 to alanine (A)."
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"These results further indicated that the phosphorylation of eIF3f by CDK11 p46 contributes to its increased association with eIF3 core complex and apoptosis."
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"We previously showed that eIF3f is phosphorylated by CDK11 p46 which is an important effector in apoptosis."
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"EIF3f can be phosphorylated by CDK11 p46 during apoptosis [XREF_BIBR]."
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"We demonstrated that eIF3f is directly phosphorylated by CDK11 p46 in vivo."
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