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USP18 activates autophagy. 8 / 8
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"Previous studies demonstrated that USP18 plays a significant role in regulating autophagy: USP18 decreased paclitaxol sensitivity of triple-negative breast cancer via promoting autophagy [26]; USP18 overexpression could promote autophagy to inhibit cell apoptosis induced by spinal cord ischemia–reperfusion injury [27]; USP18 stabilizes cGAS through deubiquitination, enhancing autophagy in melanoma cells and thereby promoting resistance to vemurafenib in BRAF V600E mutant melanoma [28]."
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"Therefore, by inducing autophagy, the USP18/cGAS axis could regulate the resistance to vemurafenib in BRAF V600E mutant melanoma.To sum up, the present study found that USP18 could stabilize cGAS prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, USP18 could induce autophagy to promote the resistance to vemurafenib in BRAF V600E mutant melanoma cells in nude mice by stabilizing cGAS expression.BRAF inhibitors or a combination of BRA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, Overexpression of USP18 enhanced autophagy to inhibit cell apoptosis induced by SCII in vivo and in vitro."
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"USP18 positively regulates autophagy by modifying BECN1 protein [ 24 ]."
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"Mechanistically , USP18 induced autophagy , an important pathway in chemotherapy resistance ."
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"In addition, ISGylation of BECN1 inhibits PI3KC3 complex activation, which plays a pivotal role in autophagy, and USP18 positively regulates autophagy by promoting de-ISGylation of BECN1 [36, 37]."
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"It has been reported that USP18, an important protein involved in chemotherapy resistance, can induce autophagy, and inhibition of USP18 can effectively inhibit tumor resistance to the chemotherapy dr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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