IndraLab

Statements

Phosphatidylinositol phosphate activates KCNH2. 9 / 9
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"The application of exogenous PIP 2 enhances hErg1 activation, and depletion of native PIP 2 causes a small reduction in hErg1 currents."
26503718
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"In this configuration, hERG and KCNQ1 biophysical changes induced by PIP 2 insertion are quite similar (slowed deactivation with no effect on activation)."
20712994
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"PIP 2 does appear to enhance hErg1 through open-state stabilization, but currently only the distal C terminus of hErg1 has been linked to PIP 2 -depenent modulation."
26503718
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"To confirm the PIP 2 modulation of hERG, we added 5 mu mol/L PIP 2 when the biophysical parameters were stable."
20712994
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"PIP (2) increased the hERG maximal current and concomitantly slowed deactivation."
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"Erg1 is not modulated by PIP 2 in a bimodal fashion and like all Erg and Eag subfamily channels intriguingly lacks a basic residue at the equivalent position of R479 (XREF_FIG)."
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"The human ether-a-go-go related gene (HERG) K channel, which is known to be modulated by PIP , is inhibited by cholesterol enrichment via increased phospholipase C (PLCβ1) expression [16]."
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"In this study, the giant-patch experiments on COS cells confirmed the activating effect of PIP 2 on hERG and showed that PIP 2 could strongly increase hERG current, notably by increasing its maximal a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20712994
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"PIP 2 modulates hERG by increasing its maximal current, concomitantly slowing deactivation, and changing activation and inactivation gating; at low PIP 2 levels, a marginal hERG current persists [XREF_BIBR]."
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