IndraLab

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USP37 activates S phase. 2 / 2

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"The deubiquitinase (DUB) USP37 has been found to stabilize cyclin A by removing the polyubiquitin from the latter and, hence, accelerates entry into S phase (Huang et al., 2011)."

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"USP37 was also reported to remove ubiquitin chains from Cyclin A and overexpression of USP37 promotes Cyclin A accumulation and accelerated S phase entry, suggesting a potentially key role for USP37 in regulating the cell cycle in a cancer setting (73)."

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IndraLab

Statements

USP37 activates S phase. 2 / 2

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