IndraLab

Statements

USP37 activates S phase. 4 / 4
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"Importantly, USP37 expression rescued chromatin-bound CDC45 in S phase, indicating a direct and specific role for USP37 in preventing replisome disassembly (Fig. 2D and E)."
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"USP37 was also reported to remove ubiquitin chains from Cyclin A and overexpression of USP37 promotes Cyclin A accumulation and accelerated S phase entry, suggesting a potentially key role for USP37 in regulating the cell cycle in a cancer setting (73)."
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"The deubiquitinase (DUB) USP37 has been found to stabilize cyclin A by removing the polyubiquitin from the latter and, hence, accelerates entry into S phase (Huang et al., 2011)."
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"USP37 promotes S phase entry by activating CDK2 and regulates cell proliferation by stabilizing p27 ( Huang et al., 2011 ; Das et al., 2013 ), and USP39 inhibits malignant proliferation of several tum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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