IndraLab

Statements

Hsp90 inhibitor activates KCNH2. 3 / 3
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"It has previously been demonstrated that the Hsp90 inhibitor, geldanamycin, inhibits hERG trafficking, presumably through an Hsp90 dependent mechanism."
22554505
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"In our previous study, we found that geldanamycin, an Hsp90 inhibitor, abolished the kinase dependent increase in HERG abundance."
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"The specific Hsp90 inhibitor geldanamycin prevents maturation and increases proteasomal degradation of hERG WT, while reducing hERG currents in heterologous expression systems."
12775586