IndraLab

Statements


PK inhibits KCNH2. 2 / 2
| 2

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"However, due to differences between hERG and Kv1.5 in terms of their three extracellular linkers (length, sequence, and 3D structure), PK cleaves hERG in the S5-S6 linker and eliminates I hERG, wherea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Our present study revealed that while PK cleaves hERG at the S5-S6 linker and abolishes I hERG, it cleaves Kv1.5 at the S1-S2 linker and does not decrease I Kv1.5."