IndraLab

Statements

USP11 activates EIF4B. 4 / 4
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"USP11 deubiquitinates and stabilizes the translation initiation factor EIF4B to promote EIF4B-dependent oncogenic translation, thus phosphorylating USP11 enhances the stability and abundance of EIF4B, which ultimately facilitates the occurrence of lymphoma."
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"A sequential co-inhibition of PI3K signaling (PI3K, Akt, mTOR, and p70-RSK) along with C75 indicated that constitutively active PI3K signaling regulates USP11 mediated eIF4B protein stability."
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"However, USP11 could also promote tumorgenesis by stabilizing Snail, eIF4B and cIAP2 [22,37,38]."
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"USP11 stabilizes and enhances Eukayotic translation initiation factor 4B (eIF4B) activity and promotes oncogenic translation in diffuse large B cell lymphoma (DLBCL) (34)."
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