IndraLab

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Baicalein inhibits NLRP3. 13 / 13
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"Mechanism of Baicalein in Brain Injury After Intracerebral Hemorrhage by Inhibiting the ROS/NLRP3 Inflammasome Pathway."
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"Notably, baicalein also inhibited NLRP3 activation and suppressed the cleavage of caspase-1 and GSDMD in the SNc as well as in mixed cultured glial cells."
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"Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model."
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"EGCG , citral , and baicalein downregulate NLRP3 levels by decreasing ROS , thereby reducing IL-1beta and IL-18 secretion ."
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"Baicalein attenuated HP by inhibiting the NLRP3/Caspase-1 pathway."
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"Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D dependent pyroptosis."
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"Baicalein inhibited the high expression of NLRP3 inflammasome in ICH."
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"Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D (GSDMD)-dependent pyroptosis."
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"Baicalein reduced the activation of the NLRP3 inflammasome."
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"The results of the study suggest that baicalein inhibits pyroptosis in Mtb-infected macrophages by downregulating the assembly of AIM2 and NLRP3 inflammasome and promoting autophagy."
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"Notably , baicalein also inhibited NLRP3 activation and suppressed the cleavage of caspase-1 and GSDMD in the SNc as well as in mixed cultured glial cells ."
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"Western blotting demonstrated significantly increased expression of NLRP3 , pro-caspase-1 , and cleaved-caspase-1 in brain SN tissue from MPTP-treated mice compared with control mice , suggesting activation of the NLRP3 inflammasome pathway ( NLRP3 , P < .01 , cleaved caspase-1 , P < .01 ; Figure 3C , D ) , and baicalein dose-dependently reduced NLRP3 activation ( NLRP3 , F4 , 10 = 29.16 , 140 mg / kg , 280 mg / kg , and 560 mg / kg , P < .01 ; cleaved caspase-1 , F4 , 10 = 16.02 , 560 mg / kg , P < .01 ; Figure 3C , D ) ."
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"Collectively, these findings indicated that baicalein can attenuate NLRP3 induced neuroinflammation in a MPTP induced PD model."
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