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Baicalein inhibits NLRP3. 26 / 26
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"However, these effects were attenuated following Baicalein treatment, indicating that Baicalein inhibits the NLRP3 inflammasome.In conclusion, Baicalein effectively inhibited the NLRP3 inflammasome and mitigated placental inflammation and oxidative stress associated with GDM in mice."
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"These findings indicated that baicalein inhibited the NLRP3/Caspase-1 pathway via the miR-192-5p axis and thus alleviated pyroptosis and inflammatory response.HP is a severe complication with extrapan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Western blotting demonstrated significantly increased expression of NLRP3 , pro-caspase-1 , and cleaved-caspase-1 in brain SN tissue from MPTP-treated mice compared with control mice , suggesting activation of the NLRP3 inflammasome pathway ( NLRP3 , P < .01 , cleaved caspase-1 , P < .01 ; Figure 3C , D ) , and baicalein dose-dependently reduced NLRP3 activation ( NLRP3 , F4 , 10 = 29.16 , 140 mg / kg , 280 mg / kg , and 560 mg / kg , P < .01 ; cleaved caspase-1 , F4 , 10 = 16.02 , 560 mg / kg , P < .01 ; Figure 3C , D ) ."
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"Some phytochemicals have demonstrated promise in blocking the NLRP3 inflammasome and managing LN, including curcumin, baicalein, sophocarpine, glycyrrhizic acid, and magnolol [201]."
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"The results of the study suggest that baicalein inhibits pyroptosis in Mtb-infected macrophages by downregulating the assembly of AIM2 and NLRP3 inflammasome and promoting autophagy."
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"Mechanism of Baicalein in Brain Injury After Intracerebral Hemorrhage by Inhibiting the ROS/NLRP3 Inflammasome Pathway."
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"Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model."
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"Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D dependent pyroptosis."
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"Notably, baicalein also inhibited NLRP3 activation and suppressed the cleavage of caspase-1 and GSDMD in the SNc as well as in mixed cultured glial cells."
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"Collectively, these findings indicated that baicalein can attenuate NLRP3 induced neuroinflammation in a MPTP induced PD model."
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"In pneumocystis carinii-infected rats NLRP3 activation is inhibited by baicalein tetrazole ."
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"These results suggested that baicalein inhibited the NLRP3/Caspase-1 pathway and alleviated cell pyroptosis and inflammatory response through the miR-192-5p/TXNIP axis.In summary, this study revealed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NLRP3 inflammasome is an important pathway activates the neuroinflammation of AD, baicalein was reported to inhibit the high expression of NLRP3 inflammasome in brain after intracerebral hemorrhage ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably , baicalein also inhibited NLRP3 activation and suppressed the cleavage of caspase-1 and GSDMD in the SNc as well as in mixed cultured glial cells ."
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"Baicalein reduced the activation of the NLRP3 inflammasome."
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"In conclusion, Baicalein inhibits the NLRP3 inflammasome and alleviates placental inflammation and oxidative stress associated with GDM."
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"In agreement with our findings, baicalein, a traditional Chinese medicine, inhibited the NLRP3/caspase-1 pathway in a MPTP mouse PD model and subsequently attenuated dopaminergic neurodegeneration and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In hyperlipidemic pancreatitis, Baicalein modulates the miR-192-5p/TXNIP axis to inhibit the NLRP3/Caspase-1 pathway, thereby mitigating pyroptosis and inflammation [9]."
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"Despite these findings, the regulatory effects and mechanisms of Baicalein in GDM progression in vivo remain unexplored.In this study, we demonstrate that Baicalein inhibits the NLRP3 inflammasome and alleviates placental inflammation and oxidative stress in a GDM mouse model, suggesting that Baicalein holds potential as a therapeutic agent for managing GDM.2 Materials and methods."
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"Previous studies have described that baicalein inhibits NLRP3 inflammasome in myeloid-derived suppressor cells ( Li et al., 2019 )."
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"Baicalein also inhibited the activation of caspase-1 and NLRP3 and decreased gasdermin D (GSDMD)-dependent pyroptosis."
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"Baicalein inhibited the high expression of NLRP3 inflammasome in ICH."
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"GL-V9 is a derivative of baicalein, which degrades NLRP3 inflammasomes by inducing autophagy, and can also delay colon cancer progression and tumorigenesis (111)."
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"Baicalein Effectively Inhibits NF-kappaB and NLRP3 Inflammasome Pathway in Ang II-Induced VSMCs."
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"Baicalein inhibits pyroptosis by promoting autophagic degradation of AIM2 and NLRP3 inflammasomes."
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"Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D (GSDMD)-dependent pyroptosis."
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