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PSMD14 inhibits Proteasome. 7 / 8
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"Koulich et al. recently demonstrated that siRNA interference of PSMD14 remarkably decreased cellular proteasome activity via disrupted 26S proteasome assembly and inhibited cellular protein degradatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca2+ Imbalance."
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"In cancer cells, RNAi of PSMD14 decreased proteasome activity and inhibited cell growth."
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"Rpn11-inhibited proteasomes can therefore move this substrate far enough into the 20S core for proteolysis near fluorescein, before translocation stalls on the K2-attached ubiquitin chain xref ."
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"One of the proteasome genes overexpressed here, PSMD14, when depleted, severely decreased proteasome proteolytic activity and led to significant inhibition of FANCD2 monoubiquitination [59]."
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"In summary, we propose a simplified mode of action regarding the effects of PSMD14 knockdown in H1299 cells as follow : down-regulation of PSMD14 with siRNA disrupts the function of 26S proteasome and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data confirmed that POH1 depletion attenuates the proteasome mediated degradation of p53 and Bim."
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