IndraLab

Statements

PSMD14 inhibits Proteasome. 9 / 10
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"Depending on the length and sequence of a substrate’s initiation region as well as the position and/or length of a ubiquitin chain, the Rpn11/ubiquitin-mediated attenuation of the proteasome conformational switching could become critical for successful substrate engagement, and substrate delivery through Rpn10’s UIM could therefore be more favorable compared to the Rpn1 or Rpn13 receptors."
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"One of the proteasome genes overexpressed here, PSMD14, when depleted, severely decreased proteasome proteolytic activity and led to significant inhibition of FANCD2 monoubiquitination [59]."
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"Koulich et al. recently demonstrated that siRNA interference of PSMD14 remarkably decreased cellular proteasome activity via disrupted 26S proteasome assembly and inhibited cellular protein degradatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca2+ Imbalance."
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"In summary, we propose a simplified mode of action regarding the effects of PSMD14 knockdown in H1299 cells as follow : down-regulation of PSMD14 with siRNA disrupts the function of 26S proteasome and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"POH1 is essential for viability, and POH1 knockdown inhibits proteasome activity and reduces cell survival [33]."
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"These data confirmed that POH1 depletion attenuates the proteasome mediated degradation of p53 and Bim."
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"The formation of Ub 1 and Ub 2 substrates upon Rpn11 reactivation is likely enabled by some mechanical unfolding of the first and second ubiquitin during substrate incubation with the Rpn11-inhibited [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Rpn11-inhibited proteasomes can therefore move this substrate far enough into the 20S core for proteolysis near fluorescein, before translocation stalls on the K2-attached ubiquitin chain xref ."
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