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USP19 binds ACSL4. 5 / 5
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"This hypothesis was supported by co‐immunoprecipitation assays, which demonstrated that wild‐type ZDHHC2 overexpression significantly reduced the ACSL4‐USP19 protein–protein interaction (Figure  xref ; Figure  xref , Supporting Information ), but did not influence the binding between ACSL4 and the USP19 C152S mutant, which cannot be palmitoylated by ZDHHC2 (Figure  xref )."
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"Meanwhile, compared to enzalutamide‐sensitive cell lines, the ACSL4‐USP19 protein–protein interaction was weakened in resistant cell lines, which matches our hypothesis (Figure  xref , Supporting Information)."
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"PLA was performed to analyze the interaction between USP19 and ACSL4 after ZDHHC2 knockdown."
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"Coimmunoprecipitation was performed using three CRPC cell lines to demonstrate the endogenous interaction between USP19 and ACSL4 (Figure  xref , Supporting Information)."
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"ZDHHC2 knockdown significantly enhanced the interaction between USP19 and ACSL4 (Figure  xref )."
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