IndraLab

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USP22 increases the amount of SOS1. 3 / 3
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"Indeed, USP22 overexpression induces significant elevations in protein levels of SOS1, RAS, p-ERK, p-PI3K, and p-AKT in both SGC7901 cells and tumors."
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"Lim et al. proposed that USP22 upregulates SOS1 expression in GC, thus leading to the activation of RAS/ERK and RAS/PI3K/AKT pathways [52]."
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"The results showed that overexpression of USP22 induced considerable upregulation of SOS1 expression in SGC7901 cells, accompanied by significant upregulation of RAS, p-ERK, c-myc, p-PI3K, and p-AKT (Fig. 5b, left panel)."
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