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"We have also recently shown that both PIF (Whitehouse and Tisdale, 2003) and 15 (S)-hydroxyeicosatetraenoic acid (15 (S)-HETE), an intracellular signal for the increased protein degradation induced by PIF (Whitehouse et al, 2003), cause degradation of IkappaBalpha and nuclear accumulation of NF-kappaB, associated with an increased proteasome expression."