IndraLab

Statements

COPS5 inhibits BMP. 10 / 10
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"Previously we showed that Jab1 negatively regulates BMP signaling in chondrocytes (Chen et al., 2013)."
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"Furthermore, Jab1 represses chondrocyte hypertrophy in vivo, likely in part by down-regulating BMP signaling."
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"Jab1 cKO limb bud cells had significantly decreased BMP reporter activity compared with wild-type littermate controls (XREF_FIG)."
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"Moreover, several studies have shown that Jab1 inhibits BMP signaling by negatively regulating Smad1/5 (14, 37, 43)."
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"Jab1 has been reported to interact with Smad5 and cause an attenuation of BMP dependent transcriptional responses, suggesting that Jab1 might act as an inhibitor of BMP signaling XREF_BIBR."
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"Together, our study demonstrates that Jab1 represses chondrocyte hypertrophy in vivo, likely in part by downregulating BMP signaling and Runx2 activity."
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"By degrading Smad4 or Smad7, Jab1 can repress or increase TGF-beta and BMP signaling, respectively, in vitro."
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"Moreover , several studies have shown that Jab1 inhibits BMP signaling by negatively regulating Smad1 / 5 ( 14 , 37 , 43 ) ."
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"Thus, Jab1 might negatively regulate BMP signaling during chondrocyte differentiation in part by sequestering Smad1/5/8 away from Acvr1."
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"In contrast, previously we have shown that Jab1 represses BMP signaling in differentiating chondrocytes, using a Col2a1-Cre transgene to achieve chondrocyte specific Jab1 knockout."
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