IndraLab

Statements

PKA activates HCN4. 4 / 4
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eidos
"HCN2 and HCN4 are modulated by cAMP and PKA , which might be selectively targeted [ 311 ] ."
33063247
reach
"These four alanine substitutions eliminated the ability of PKA to shift the voltage dependence of HCN4-Cx4 channels (V 1/2 = -105.0 +/- 3.7 mV, n = 8 in control, -107.5 +/- 1.7 mV, n = 6 in PKA; XREF_FIG and XREF_FIG), indicating that this regulatory site is obligatory for modulation of HCN4 by PKA."
20713547
reach
"By a deletion and mutagenesis strategy, they could pinpoint a region in the distal C terminus containing four PKA sites that was necessary for the PKA modulation of HCN4 channels (XREF_FIG)."
20713549
reach
"HCN4 is the predominant cAMP gated channel for I f in SANC 32 and new studies show that HCN4 is also activated by PKA phosphorylation."
21406683