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YOD1 deubiquitinates PML. 2 / 2

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"Taken together, these results strongly indicate that YOD1 regulates the stability of both the wild-type and mutant forms of PML/RARα.3.3 YOD1 deubiquitinates wild-type PML/RARalpha and its drug-resistant mutants."

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"Results reveal that purified YOD1 effectively deubiquitinated PML/RARα in vitro, while YOD1(C160S) failed to deubiquitinate PML/RARα (Fig. 3F), confirming the importance of YOD1 catalytic activity to PML/RARα deubiquitination."

35847510

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YOD1 deubiquitinates PML. 2 / 2

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