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Chloroform increases the amount of USP22. 2 / 2
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"TCM from B16 and LLC1, but not EG7 cells, enhanced Usp22 and Usp21 mRNA levels (Fig. 2A)."

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"To support this notion, we further demonstrated that the TGF-β inhibitor completely diminished the TCM-induced mRNA enhancement of Usp22 (Fig. 2C), signifying that TGF-β is the primary factor in the B16 and LLC1 TCM that enhances Usp22 expression."