IndraLab

Statements

USP30 inhibits Ubiquitin. 3 / 3
| 3
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"In the mammalian system, Usp30 deubiquitinase was shown to localize to mitochondria and antagonize the ubiquitin ligase Parkin-mediated mitophagy [63]."
30249207
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"The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Parkin substrates."
35250566
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"The OMM localized DUB ubiquitin specific processing proteases USP30 and USP15 antagonize PARKIN activity by cleaving ubiquitin chains on mitochondria."
28512624