IndraLab

Statements

USP30 inhibits Ubiquitin. 13 / 13
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"The OMM localized DUB ubiquitin specific processing proteases USP30 and USP15 antagonize PARKIN activity by cleaving ubiquitin chains on mitochondria."
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"For example, USP15, USP30, and USP35 are known to eliminate the ubiquitin- and parkin-mediated signals, consequently delaying or disrupting mitophagy (5)."
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"USP30 upregulation reverses ubiquitin chain‐linkages on OMM proteins that are added by parkin."
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"The E3 ligase Parkin ubiquitinates the membrane proteins on targeted mitochondria to initiate mitophagy, whereas USP30 antagonizes Parkin-dependent mitophagy by removing ubiquitin from Parkin substrates."
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"In the mammalian system, Usp30 deubiquitinase was shown to localize to mitochondria and antagonize the ubiquitin ligase Parkin-mediated mitophagy [63]."
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"Although PINK1/Parkin-mediated mitophagy has been well studied, no effective drug targeting this pathway has been employed for the treatment of neurodegenerative diseases.As a negative feedback mechan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The simplest model predicts that peroxisome-localised USP30 suppresses critical ubiquitin signals, linked to quality control, that otherwise lead to pexophagy (22, 23)."
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"The available data suggest that USP30 mainly acts to prevent inadvertent mitophagy by constitutively removing ubiquitin moieties from mitochondria."
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"Current therapeutic strategies primarily focus on blocking mitochondrial USP30, which antagonizes Parkin by removing ubiquitin from the mitochondrial surface."
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"It is in line with the role of USP30 in eliminating ubiquitin from mitochondrial proteins."
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"We propose that if USP30 prevents pexophagy by removing ubiquitin on peroxisomes, then overexpressing USP30 should prevent NBR1 recruitment to peroxisomes during starvation."
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"USP15, USP30 and USP35 inhibit mitophagy by removing the ubiquitin signal from Parkin targets [46–48]."
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"This further supports the hypothesis that USP30 prevents pexophagy by removing ubiquitin on peroxisomes."
30700497